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i-Lipo’s New Clinical Paper – France

before-after-fat-cellsSummary of Paper:

The study was a prospective evaluation of 15 patients (12 women, 3 men) during a course of 8 i-Lipo treatment sessions over 4 weeks.  The included subjects were chosen as having a history of ‘resistant’ anatomical areas that had previously demonstrated nil improvement to regular gym exercise and diet control alone.  7 subjects had treatments on the thigh, 8 subjects had abdominal treatments.  Direct circumference measurements of treated anatomy and echography measurements of fat layer thickness were recorded.

The second part of the study, histological and biological analysis was performed on human skin explants maintained in survival conditions, using light microscopy and assaying glycerol collagen synthesis levels after 5 ilipo simulated treatments on the tissue versus control (untreated) tissue.

The pertinent results to highlight are that:

Circumference Measurements:

An average of 4.16cm was reduced from (8) abdominal treatments

An average of 1.5cm was lost from (8) thigh treatments


Echography (Ultrasound fat thickness measurements):

  • An average of 5.1mm reduction in fat layer thickness without compression, 1.75mm reduction with compression
  • An average of 5.6mm reduction in fat layer thickness, 4.0mm with compression
  • Overall, for all subjects, an average thickness reduction in adipose tissue of 18%


Reduction of Fatty tissue (Kg):

  • An average of 4.8% reduction in mass of fatty tissue in the abdomen (8) treatments
  • An average of 2.41% reduction in mass of fatty tissue in the thigh (8) treatments
  • One subject reduced fatty tissue mass by 7.84% during their treatments (8)


Histological Analysis using Light Microscopy:

  • Visible thinning of the hypodermis (fat layer)
  • Reduction of average fat cell size
  • Reduction of fibrosis divisions between the fat lobules
  • Modification of fat cell membranes including flattening or elongation of the fat cell shape compared to the normal globular shape of filled capacity fat cells
  • No observed necrosis or destruction of adjacent structures (epidermis, microvasculature, dermal collagen)


Biochemical Analysis:

  • Increase in measured Glycerol levels to 233.5μg/g fat in ilipo treatment tissue versus 177.16μg/g for control (untreated) areas (p=0.043) representing an increase of approximately 30%
  • Increase in measured collagen synthesis to 46.2μg/mg tissue in ilipo treatment tissue versus 40.25μg/mg in control (untreated) tissue (p=0.001), representing an increase in collagen synthesis of approximately 15%.  This collagen will act to restructure the dermis and hypodermis following shrinkage of the fatty tissue, improving the visible appearance of cellulite and potentially slowing or preventing relapse of the condition.


Updated on: Wednesday, November 30th, 2016